After 80 years, scientists are testing out this once-forgotten antibiotic's ability to combat today's difficult-to-treat bacteria.
, the team looked closely at streptothricin-F and also streptothricin- D. Streptothricin-D strain was also highly selective for the gram-negative bacteria and was even more powerful than streptothricin-F against drug-resistant Enterobacterales and other bacterial species. However, it caused renal toxicity at a lower dose.
The team used cryo-electron microscopy to show that streptothricin-F bound extensively to a subunit of the bacterial ribosome. This binding causes translation errors in the bacteria, which helps“It works by inhibiting the ability of the organism to produce proteins in a very sneaky way. When a cell makes proteins, they make them off a blueprint or message that tells the cell what amino acids to link together to build the protein.
“We have great collaborators that have allowed us to pursue a project that crosses multiple fields. This work is an example of collaborative science really at its best,” said Kirby.
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Philadelphia Inquirer hit by cyberattack causing newspaper's largest disruption in decadesThe Philadelphia Inquirer has experienced the most significant disruption to its operations in 27 years due to what the newspaper calls a cyberattack
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Philadelphia Inquirer hit by cyberattack causing newspaper's largest disruption in decadesThe Philadelphia Inquirer has experienced the most significant disruption to its operations in 27 years due to what the newspaper calls a cyberattack.
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